In Path of Exile 2, poison is a significant mechanic that can deal substantial damage over time, making effective defenses against it crucial for survival. This article explores various strategies and items to mitigate poison damage, focusing on the Antidote Charm, passive skills, and gear choices.

Poison Damage

Poison in PoE 2 is classified as a chaos damage over time effect that bypasses energy shields, dealing damage directly to health. It typically lasts for two seconds and can stack if multiple sources of poison are applied. The damage dealt by poison is influenced by the initial hit’s physical or chaos damage and can be further enhanced by specific modifiers and passive skills.

Key Defenses Against Poison

Antidote Charm

The Antidote Charm is a vital item for players facing poison-heavy encounters. Here are its key features:

• Immunity Activation: Grants immunity to poison for 3 seconds upon being poisoned.
• Automatic Use: Activates automatically without requiring player input.
• Charges: Starts with 80 charges, consuming 40 per use, which can be replenished by defeating enemies or using Wells.
• Level Requirement: Requires level 24 to equip.

This charm is particularly useful in areas dense with poison traps or when battling bosses that heavily utilize poison attacks.

Managing Your PoE 2 Currency for Optimal Defenses

In your journey through Path of Exile 2, it's essential to manage your resources wisely, especially when it comes to gear and defenses against poison damage. Acquiring the right items may require investing in PoE 2 Currency. Players often find that trading for specific gear or enhancements can significantly impact their survivability in poison-heavy encounters. By understanding the market and knowing when to buy PoE 2 Currency, you can ensure you have the necessary resources to bolster your character's defenses effectively.

For those looking to streamline their acquisition of PoE 2 Currency, platforms like U4GM offer invaluable assistance. U4GM provides a secure and efficient marketplace where players can purchase the currency directly, allowing for a more focused gameplay experience. With the currency in hand, you can prioritize acquiring the Antidote Charm and other essential gear to mitigate poison damage effectively. Investing in these resources through U4GM can lead to a marked improvement in your character's performance, giving you the edge needed to thrive in the challenging world of Path of Exile 2.

Passive Skills

Investing in specific passive skills can significantly enhance your defenses against poison:

• Chaos Resistance: Increasing chaos resistance is crucial since poison damage is classified as chaos damage. Higher chaos resistance reduces the overall damage taken from poison effects.
• Low Tolerance: This notable passive skill increases the effectiveness of your poison skills while providing some defensive benefits against incoming damage.
• Catalysis: This passive provides a defensive mechanism by converting a portion of physical damage taken into elemental damage, allowing for better survivability against certain attacks.

Gear Choices

Choosing the right gear can further bolster your defenses against poison:

• Life and Evasion Gear: Stacking life and evasion helps mitigate damage from hits that may lead to poisoning. This baseline defense is essential for all builds but especially for those vulnerable to one-shot mechanics.
• Chaos Resistance Gear: Look for items that provide additional chaos resistance to reduce the effectiveness of poison attacks. This is particularly important when facing enemies known for their heavy reliance on chaos damage.

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